2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-108590
    DMP-543 160588-45-4 99.96%
    DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer.
    DMP-543
  • HY-108619
    Gisadenafil besylate 334827-98-4 ≥99.0%
    Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor with an IC50 of 3.6 nM and prevents degradation of cyclic guanosine monophosphate (cGMP).
    Gisadenafil besylate
  • HY-108678
    TC OT 39 479232-57-0
    TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC50=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an Ki value of 330 nM. TC OT 39 exhibits sedative effects in mouse models.
    TC OT 39
  • HY-109077
    Tigolaner 1621436-41-6 99.37%
    Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity.
    Tigolaner
  • HY-109841
    Oleoyl serotonin 1002100-44-8 98.28%
    Oleoyl Serotonin (compound 1e) is a TRPV1 antagonist with IC50 value of 2.57 μM for human TRPV1.
    Oleoyl serotonin
  • HY-110087
    4BP-TQS 360791-49-7 99.89%
    4BP-TQS is a potent allosteric agonist of α7 nAChR. 4BP-TQS activates nAChRs via an allosteric transmembrane site.
    4BP-TQS
  • HY-110140
    (E)-KN-93 phosphate 1188890-41-6 99.85%
    (E)-KN-93 phosphate is a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with IC50 values of 9 μM and 3 μM against CaMKIIδMonomer and CaMKIIδDodecamer, respectively. (E)-KN-93 phosphate can be used in research on epilepsy, depression, and arrhythmias..
    (E)-KN-93 phosphate
  • HY-110152
    LSN2463359 1401031-52-4 98.49%
    LSN2463359 is positive allosteric modulator of metabotropic glutamate 5 (mGlu5). LSN2463359 attenuates aspects of the behavioral response to administration of the competitive NMDA receptor antagonist. LSN2463359 selectively attenuates reversal learning deficits observed in the neurodevelopmental MAM E17 model. LSN2463359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    LSN2463359
  • HY-110157
    AC-186 1421854-16-1 99.61%
    AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease.
    AC-186
  • HY-110259
    HFI-142 332164-34-8 ≥99.0%
    HFI-142 is an insulin-regulated aminopeptidase (IRAP) inhibitor with a Ki of 2.01 μM.
    HFI-142
  • HY-110285
    ML382 1646499-97-9 99.89%
    ML382 is a potent and selective MRGPRX1 (Mas-related G protein-coupled receptor X1, MrgX1) positive allosteric modulator, with an EC50 of 190 nM.
    ML382
  • HY-111911
    Xanthocillin X permethyl ether 4464-33-9 98.90%
    Xanthocillin X permethyl ether is a natural compound isolated from fungal extracts, with Aβ-42 lowering activity.
    Xanthocillin X permethyl ether
  • HY-111935
    3,3'-Diethyl-9-methylthiacarbocyanine iodide 3065-79-0 98.93%
    3,3'-Diethyl-9-methylthiacarbocyanine iodide is a cyanine dye, also a tau aggregation inhibitor, with an IC50 value of 0.28 μM for tau. 3,3'-Diethyl-9-methylthiacarbocyanine iodide can cause misfunction of the microtubule cytoskeleton. 3,3'-Diethyl-9-methylthiacarbocyanine iodide can be used for researching Alzheimer’s disease.
    3,3'-Diethyl-9-methylthiacarbocyanine iodide
  • HY-112465
    H-8 dihydrochloride 113276-94-1 99.19%
    H-8 dihydrochloride is a selective Cyclic nucleotide-dependent protein kinase inhibitor. H-8 dihydrochloride potently inhibits cGMP- and cAMP-dependent protein phosphorylation. H-8 dihydrochloride enhances the vasodilatory effect induced by 8-bromo-cAMP (HY-12306A). H-8 dihydrochloride fails to attenuate the vasodilatory effects induced by 8-bromo-cGMP (HY-101379A), atrial natriuretic peptide II, or Sodium nitroprusside (HY-B0564) in rat aorta.
    H-8 dihydrochloride
  • HY-112722
    Neurotoxin Inhibitor 951571-70-3 99.02%
    Neurotoxin Inhibitor is a neurotoxin inhibitor. Neurotoxin Inhibitor promotes the expression of DJ-1 protein, reduces the level of oxidative stress, and thereby protects dopaminergic neurons. Neurotoxin Inhibitor can be used for the study of Parkinson's disease.
    Neurotoxin Inhibitor
  • HY-112855
    PF-06454589 1527473-30-8 99.91%
    PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research.
    PF-06454589
  • HY-115366
    Soluflazine 112415-83-5 98.04%
    Soluflazine is a nucleoside transport inhibitor with anticonvulsant action. Soluflazine can be used as an antiepileptic agent.
    Soluflazine
  • HY-115674
    ML175 610263-01-9 99.37%
    ML175 is a specific glutathione transferase Omega 1-1 (GSTO1-1) inhibitor. ML175 can significantly activate Akt and MEK1/2 kinases. ML175 can be used in the research of diseases such as Parkinson's disease.
    ML175
  • HY-115681
    (2R/S)-6-PNG 68682-01-9 ≥99.0%
    (2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible Cav3.2 T-type Ca2+ channels (T-channels) blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice.
    (2R/S)-6-PNG
  • HY-116463
    E1R 1301211-78-8 99.83%
    E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity.
    E1R
Cat. No. Product Name / Synonyms Application Reactivity